San Francisco is a world leader if not the main leader for innovation. It is also a very important part of Silicon Valley.
Despite high real estate and living costs in San Francisco, the city at the top of the hill remains the most innovative city in the country. Manhattan leads more in the Wall Street business side. Other places like Israel Singapore Hong Kong and India rival but still do not meet the level of innovation found in San Francisco.
Many of the tech innovations with Steve Kays, from Innovation Institute, Inc originated in San Francisco Richmond District.